Several questions about the ongoing HCV transmission among MSM can be addressed using MS-TRACE. Examples of possible analytic approaches are featured here, using Nextstrains’ narrative. Narratives are a method to tell a story using the genomic data of MS-TRACE.
Clustering of sequences
In this narrative we look at the clustering patterns of the sequences in our dataset.
We answer questions such as: What are the trends in clustering? When were clusters introduced? What influence does our clustering-algorithm have?
Prep and HCV Transmission
In this narrative we look at clustering patterns of MSM using PrEP in Amsterdam. We answer questions such as: Are there PrEP specific clusters in Amsterdam? How do PrEP users cluster with HIV-infected individuals?
In this narrative we look at the potential transmission of resistance-associated substitutions (RAS). We answer questions such as: Does transmission of resistance-associated substitutions occur? Which RAS are most prevalent? When were RAS introduced?